目的：观察自发性高血压大鼠（SHR）肾组织中细胞间黏附分子-1（ICAM-1）和血管细胞黏附分子-1（VCAM-1）表达及冬虫夏草制剂对其影响。方法：清洁级雄性SHR 22只、WKY大鼠6只(W组)，SHR随机分为非干预组（S组）、冬虫夏草制剂组（C组）、福辛普利组（F组）、冬虫夏草制剂加福辛普利组（FC组），后3组以冬虫夏草制剂4 g/(kg·d)和/或福辛普利10 mg/(kg·d)灌胃，S组及W组以等量清水灌胃，测血压，8周末测尿蛋白、血肌酐，取肾组织做HE，Masson染色，免疫组织化学及RT-PCR方法检测ICAM-1，VCAM-1蛋白及mRNA表达情况。结果：与WKY大鼠比较，SHR尿蛋白排泄量增高，肾组织ICAM-1，VCAM-1蛋白及mRNA表达增强。与S组比较，福辛普利使大鼠血压下降，而冬虫夏草制剂无明显降压作用。但C，F，FC组均有尿蛋白排泄量、血肌酐水平下降；肾组织ICAM-1，VCAM-1蛋白及mRNA表达下调。结论：高血压造成肾脏损害时可出现肾组织ICAM-1和VCAM-1的异常表达，冬虫夏草制剂可有效改善二者的异常表达，具有良好的肾保护作用。

ObjectiveTo observe the effect of Cordceps Sinensis (CS) on the expression of intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) in the kidney of spontaneously hypertensive rats(SHR), and to investigate the mechanism of CS. MethodsMale SHRs (23 week old) were randomly divided into 4 groups: a group without any treatment (Group S), a group treated with Cordceps sinensis at 4 g/(kg·d)(Group C), a group treated with fosinopril at 10 mg/(kg·d) (Group F), and a group received daily intragastric administration of CS at 4 g/(kg·d) and fosinopril at 10 mg/(kg·d) (Group CF). At the same time, 6 male WKY rats were used as normals controls. At the end of 8 weeks, all rats were sacrificed. Serum creatinine(Scr), 24 h urinary protein count, and the expression of ICAM-1 and VCAM-1 were examined by immunohistochemical technique and RT-PCR. ResultsCompared with the WKY rats, blood pressure, 24 h urinary protein count, Scr，and the expression of ICAM-1 andVCAM-1 in the kidney of SHR significantly increased (P＜0.05).Compared with Group S, blood pressure decreased after treatment by fosinopril (P＜0.05). Compared with Group S, the levels of Scr, 24 h urinary protein count, and glomerular lesion were significantly reduced in the CS and/or fosinopril treatment group. The expression of ICAM-1 and VCAM-1 was significantly decreased in these groups (P＜0.05).ConclusionCS may play a role in the protection and anti-fibrosis in the process of renal injury in SHR through reducing the expression of ICAM-1 and VCAM-1.

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